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Medication-Assisted Treatment (MAT) Explained

MAT is the gold standard for opioid use disorder and is also effective for alcohol use disorder.

Medical Disclaimer: The information on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about addiction treatment.

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Overview

Medication-assisted treatment (MAT), also called medications for opioid use disorder (MOUD) or medications for addiction treatment, combines FDA-approved medications with behavioral therapy and counseling to treat substance use disorders.

Medications by Condition

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For Opioid Use Disorder

Methadone

Full opioid agonist that stabilizes brain chemistry and reduces cravings.

Full Agonist

Buprenorphine (Suboxone)

Partial opioid agonist that reduces cravings and withdrawal without full euphoria.

Partial Agonist

Naltrexone (Vivitrol)

Opioid antagonist that blocks opioid effects. Used after detox.

Antagonist

For Alcohol Use Disorder

  • Naltrexone — reduces cravings and blocks alcohol's rewarding effects
  • Acamprosate — helps maintain abstinence by stabilizing brain chemistry
  • Disulfiram (Antabuse) — causes unpleasant reactions when alcohol is consumed

MAT is not "replacing one addiction with another." These medications stabilize brain chemistry, reduce cravings, and allow people to function normally. MAT reduces illicit opioid use by up to 90%, lowers overdose death risk, and improves treatment retention.

Related Resources

FindAddictionTreatments.com provides informational content and referral services. We are not a treatment facility. Individual treatment outcomes vary. No specific results are guaranteed.

National Resources: SAMHSA National Helpline | 988 Suicide & Crisis Lifeline: Call or text 988 | SAMHSA Treatment Locator: findtreatment.gov

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