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Overview
GHB (gamma-hydroxybutyrate) is a central nervous system depressant that occurs naturally in the brain in small amounts. In its synthetic form, it is used illicitly for its euphoric and sedative effects and has been associated with sexual assault due to its ability to incapacitate. GHB is a Schedule I controlled substance (Schedule III when in the FDA-approved formulation Xyrem for narcolepsy).
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GHB is highly addictive with regular use, and withdrawal can be severe and medically dangerous — similar to alcohol and benzodiazepine withdrawal, including risk of seizures, delirium, and autonomic instability. GHB withdrawal requires medical supervision and often hospitalization.
Treatment
Treatment involves medically supervised detox (sometimes using benzodiazepines or barbiturates), behavioral therapy, and treatment of co-occurring conditions.
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Related Resources
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National Resources: SAMHSA National Helpline | 988 Suicide & Crisis Lifeline: Call or text 988 | SAMHSA Treatment Locator: findtreatment.gov